Author

Urko del Castillo

Weill Cornell MedicineORCID 0000-0002-4170-1749Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Paraskevi GiannakakouiD· 3 shared Abhishek BoseiD· 1 shared Abigail LidoskiiD· 1 shared Abigail TayloriD· 1 shared Alejandra Laguillo-DiegoiD· 1 shared Alina Sami· 1 shared Bhavneet BhinderiD· 1 shared Bishoy M. FaltasiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersCancer Biology

Paraskevi GiannakakouORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

KAT6 and KAT7 actively maintain mitotic chromatin composition and acetylation to preserve developmental competence

Alejandra Laguillo-Diego, UkJin Lee, Xiao Liu, Abigail Lidoski, Kritika Kasliwal, Urko del Castillo, Jin Joo Kang, Stephanie Stransky, Spencer Kaufman, Bryce J Katch, Paraskevi Giannakakou, Simone Sidoli, Haiyuan Yu, Matthias Stadtfeld, Effie Apostolou

This study shows KAT6 and KAT7 maintain mitotic chromatin acetylation and composition, supporting postmitotic transcriptional memory and developmental competence in stem cells.

bioRxiv · Nov 10, 2026 · PreprintMolecular Biology

AR-V7 Utilizes a Noncanonical Nuclear Localization Signal to Sustain Androgen-Independent Nuclear Import and Signaling

Urko del Castillo, Naira Essam Abou-Ghali, Colin S. Burdette, Michelle Naidoo, CheukMan Cherie Au, Kiran Kumari Sahu, Xuanrong Chen, Xi Kathy Zhou, Jacob Geri, Paraskevi Giannakakou

This study identifies a noncanonical nuclear localization signal in AR-V7 that enables androgen-independent nuclear import and transcriptional activity, revealing distinct vulnerabilities for targeting AR-V7 signaling.

bioRxiv · Sep 24, 2026 · PreprintCancer Biology

CAR-T Targeting of Mutant Calreticulin Establishes a Potentially Curative Stem Cell-Directed Therapy for Myeloproliferative Neoplasms

Daniel C. Choi, Giovanni Medico, Irina V. Lebedeva, Elisabeth K. Nyakatura, Clarisse Kayembe, Franco Castillo Tokumori, Pouneh Kermani, Nassima Messali, Olivia Vergnolle, Abigail Taylor, Maria Mia Yabut, Urko del Castillo, Paul J. Balderes, Manuel Baca, Giorgio Inghirami, Joseph Michael Scandura

This study demonstrates that CAR-T cells targeting mutant calreticulin can eliminate MPN-propagating HSCs in xenograft models without antigen escape.

bioRxiv · Feb 11, 2026 · PreprintCancer Biology

APOBEC3A-Induced DNA Damage Drives Polymerase Theta Dependency and Synthetic Lethality in Cancer

Abhishek Bose, Weisi Liu, Paul Yoo, Alina Sami, Michal T. Boniecki, Madhura Deshpande, Mohamed Hosny Abdo Osman, Duy D. Nguyen, Urko del Castillo, Paraskevi Giannakakou, Bhavneet Bhinder, William F. Hooper, Olivier Elemento, Nicolas Robine, Milaid Granadillo, , Bishoy M. Faltas

This study identifies TMEJ as the main repair pathway for APOBEC3A-induced DSBs and shows Polθ inhibition causes synthetic lethality in cancer cells with APOBEC3A activity.

bioRxiv · Oct 21, 2025 · PreprintCancer Biology