Paraskevi Giannakakou

This study shows KAT6 and KAT7 maintain mitotic chromatin acetylation and composition, supporting postmitotic transcriptional memory and developmental competence in stem cells.

This study identifies a noncanonical nuclear localization signal in AR-V7 that enables androgen-independent nuclear import and transcriptional activity, revealing distinct vulnerabilities for targeting AR-V7 signaling.

This paper identifies FOXJ1 as a mediator of taxane resistance in prostate cancer by regulating microtubule dynamics, with clinical implications for patient stratification.

This study identifies TMPO as a driver of CTC heterogeneity and metastasis in prostate cancer by enhancing survival under metabolic stress.

This study identifies TMEJ as the main repair pathway for APOBEC3A-induced DSBs and shows Polθ inhibition causes synthetic lethality in cancer cells with APOBEC3A activity.

The paper investigates how aging-dependent dysregulation of EXOSC2 affects cellular traits and finds that PPP2R5E, a PP2A phosphatase subunit, is a key target of EXOSC2, with this regulation maintained in stem cells and cancer.

This paper introduces BANDIT, a Bayesian machine-learning framework for drug target identification, achieving 90% accuracy in predicting targets for 2000 small molecules and validating novel microtubule inhibitors and the target of ONC201.