A large pocket structure surrounding the catalytic center in the BCG protein from Mycobacterium tuberculosis
Kohei Takeshita, Naoki Sakai, Go Ueno, Midori Horie, Hirofumi Tsujino, Mitsuhiro Arisawa, Masaki Yamamoto, Masayoshi Arai, Taku Yamashita
This study determines the crystal structure of BCG3185c and identifies a large pocket near its catalytic center that may bind agelasine D, suggesting its role in inhibiting Mycobacterium tuberculosis growth.
bioRxiv · May 14, 2024 · PreprintBiochemistry