Tuning the gate and the gear: The LRRC26 (γ1) subunit modulates intrinsic gating and voltage-sensor coupling of the BK channel
Felipe Echeverría, Antonio Peña-Pichicoi, Miguel Fernandez, Willy R. Carrasquel-Ursulaez, Juan Pablo Castillo, Osvaldo Diez Alvarez, Ramón Latorre
This study shows that the γ1 subunit of BK channels increases the equilibrium constant for channel opening by destabilizing the closed state and enhancing voltage-sensor-pore coupling.
Proceedings of the National Academy of Sciences · Feb 17, 2026Peer-reviewedBiophysics