Juan Pablo Castillo

Tuning the gate and the gear: The LRRC26 (γ1) subunit modulates intrinsic gating and voltage-sensor coupling of the BK channel

This study shows that the γ1 subunit of BK channels increases the equilibrium constant for channel opening by destabilizing the closed state and enhancing voltage-sensor-pore coupling.

Interspecies relationships of wild amoebae and bacteria with C. elegans create environments propitious for multigenerational diapause.

This study shows that a natural ensemble of bacteria and amoebae induces diapause in C. elegans through RNA communication and pheromone signaling, with effects persisting across generations.