ERα-regulated IRX3 controls the growth of ER-positive breast tumors
Pouda Panahandeh, Jan-Inge Bjune, Regine Åsen Jersin, Mihaela Popa, Shuntaro Yamada, Kamal Mustafa, Emmet McCormack, Karianne Fjeld, Elisabeth Wik, Simon EN Dankel, Gunnar Mellgren
This study identifies IRX3 as an ERα-regulated gene that promotes ER+ breast tumor growth and metastasis by enhancing vascularization, with low IRX3 expression linked to poorer patient survival.
bioRxiv · May 21, 2026 · PreprintCancer Biology