Emmet McCormack

This study identifies IRX3 as an ERα-regulated gene that promotes ER+ breast tumor growth and metastasis by enhancing vascularization, with low IRX3 expression linked to poorer patient survival.

The paper uses single-cell RNA sequencing to identify resistance signatures in ovarian cancer and develops a framework for combination therapy with carboplatin.

This study develops a humanized xenograft model of high-grade serous ovarian cancer to evaluate immunotherapy, finding no treatment response but identifying immune-excluded tumor phenotypes.

This study uses ReSisTrace to identify pre-sensitizing agents for FLT3 inhibitors in FLT3-ITD-positive AML by analyzing transcriptional signatures and validating compounds that enhance treatment efficacy.