ALDH2 Deficiency Drives Proliferative Mammary Morphogenesis and Epithelial Cell Stemness via Oxidative Stress and Estrogen Receptor Activation
Zhikun Ma, Amanda B. Parris, Miles Lester, De'ja Gissendanner, Vasilis Vasiliou, Xiaohe Yang
This study shows ALDH2 deficiency promotes mammary gland proliferation and stemness through oxidative stress and estrogen receptor activation, increasing breast cancer risk.
bioRxiv · Sep 25, 2025 · PreprintCancer Biology