Xiaohe Yang

This study shows that prenatal alcohol exposure alters mammary gland development and stem cell activity in mice without tumor induction.

This study identifies prenatal ethanol-induced molecular reprogramming in newborn mammary glands, including altered insulin signaling and enhanced proliferative programming.

This study shows alcohol promotes ER+ breast cancer cell proliferation and invasion by enhancing ER-ErbB3 signaling through NRG1 upregulation.

This study shows that ALDH2 knockout in SKBR-3 cells increases cellular stress and alters arginine biosynthesis and metabolism pathways.

This study shows chronic alcohol exposure causes lasting DNA damage and makes breast cells more sensitive to PARP inhibitors.

Short-term palbociclib exposure during a premalignant risk window delays ErbB2-driven mammary tumorigenesis by suppressing stemness and proliferation.

This study shows ALDH2 deficiency promotes mammary gland proliferation and stemness through oxidative stress and estrogen receptor activation, increasing breast cancer risk.