Zhikun Ma

In Utero Alcohol Exposure Reprograms Mammary Gland Development and Stem/Progenitor Cell Activity in a Non-Tumorigenic Mouse Model

This study shows that prenatal alcohol exposure alters mammary gland development and stem cell activity in mice without tumor induction.

Transcriptomic Analysis of the Newborn Mammary Gland Identifies Prenatal Ethanol-Induced Remodeling of Insulin Signaling and Enhanced Proliferative Programming

This study identifies prenatal ethanol-induced molecular reprogramming in newborn mammary glands, including altered insulin signaling and enhanced proliferative programming.

Alcohol Promotes ER+ Breast Cancer Cell Proliferation and Invasion Through the Upregulation of Neuregulin 1-Mediated ER-ErbB3 Crosstalk

This study shows alcohol promotes ER+ breast cancer cell proliferation and invasion by enhancing ER-ErbB3 signaling through NRG1 upregulation.

ALDH2 Knockout Induces Dysregulation of Arginine biosynthesis in SKBR-3 Breast Cancer Cells

This study shows that ALDH2 knockout in SKBR-3 cells increases cellular stress and alters arginine biosynthesis and metabolism pathways.

Chronic Alcohol Exposure Induces Persistent DNA Damage Response Signaling and Sensitizes Breast Epithelial Cells to PARP Inhibition

This study shows chronic alcohol exposure causes lasting DNA damage and makes breast cells more sensitive to PARP inhibitors.

Risk-Window Palbociclib Exposure Delays ErbB2-Driven Mammary Tumorigenesis and Suppresses Mammary Epithelial Cell Stemness

Short-term palbociclib exposure during a premalignant risk window delays ErbB2-driven mammary tumorigenesis by suppressing stemness and proliferation.

ALDH2 Deficiency Drives Proliferative Mammary Morphogenesis and Epithelial Cell Stemness via Oxidative Stress and Estrogen Receptor Activation

This study shows ALDH2 deficiency promotes mammary gland proliferation and stemness through oxidative stress and estrogen receptor activation, increasing breast cancer risk.