Development of a Time-Resolved Fluorescence Resonance Energy Transfer ultra-high throughput screening assay for targeting SYK and FCER1G interaction
Yuhong Du, Dongxue Wang, Vittorio L. Katis, Elizabeth L. Zoeller, Min Qui, Allan I. Levey, O. Gileadi, Haian Fu
This paper develops a time-resolved fluorescence resonance energy transfer (TR-FRET) assay for screening small molecule inhibitors targeting the SYK and FCER1G interaction, identifying hematoxylin as a hit.
SLAS DISCOVERY · Aug 23, 2024Peer-reviewedPharmacology & Toxicology