Dongxue Wang

Towards Unmanned Proteomics Data Generation: A Fully Automated Sample-to-Data System for Proteomic Experiments

The paper introduces an automated system for high-throughput proteomic data generation, demonstrating its robustness and application in spatial proteomics and plasma/cell line profiling.

Development of a Time-Resolved Fluorescence Resonance Energy Transfer ultra-high throughput screening assay for targeting SYK and FCER1G interaction

This paper develops a time-resolved fluorescence resonance energy transfer (TR-FRET) assay for screening small molecule inhibitors targeting the SYK and FCER1G interaction, identifying hematoxylin as a hit.

Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM

The paper identifies two covalent inhibitors that disrupt the interaction between SYK's tandem SH2 domains and FCER1G phospho-ITAM, potentially beneficial for Alzheimer's disease therapy.

Differences in transcription initiation directionality underlie distinctions between plants and animalsin chromatin modification patterns at genes and cis-regulatory elements

The paper compares transcription initiation directionality in plants and animals, finding unidirectional initiation in plants and bidirectional in animals, with distinct chromatin modification patterns.

Quantification and discovery of sequence determinants of protein per mRNA amount in 29 human tissues

The paper quantifies protein-to-mRNA (PTR) ratios across 29 human tissues and identifies sequence determinants influencing these ratios, finding many new post-transcriptional regulatory elements.

A deep proteome and transcriptome abundance atlas of 29 healthy human tissues

The paper creates a proteome and transcriptome atlas of 29 human tissues, revealing differences in mRNA-protein abundance and challenges in proteogenomics.