Author

Haian Fu

Emory UniversityORCID 0000-0002-2362-7979Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1 Pharmacology & Toxicology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 3 Assay:proteomics· 2 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1

Frequent Co-Authors

Yuhong DuiD· 4 shared Allan I. LeveyiD· 3 shared O. GileadiiD· 3 shared Vittorio L. KatisiD· 3 shared Alison Donnelly AxtmaniD· 2 shared Arunima SikdariD· 2 shared Dongxue WangiD· 2 shared Elizabeth L. ZoelleriD· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersSystems Biology

Yuhong DuORCID

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4 papers

Recent·Most cited

Integrated phenotypic and proteomic screening identifies top-tier Alzheimer's disease therapeutic targets

Gregory A. Cary, Qianjin Li, Jesse C. Wiley, Carolyn A. Paisie, Yuhong Du, Elizabeth L. Zoeller, Duc Minh Duong, Haian Fu, Nicholas T. Seyfried, Allan I. Levey, Ranjita S. Betarbet, Gregory W. Carter

The paper identifies five therapeutic targets for Alzheimer's disease by integrating phenotypic and proteomic screening in murine microglial cells.

Alzheimer s & Dementia · Dec 1, 2025Peer-reviewedSystems Biology

Development of a Time-Resolved Fluorescence Resonance Energy Transfer ultra-high throughput screening assay for targeting SYK and FCER1G interaction

Yuhong Du, Dongxue Wang, Vittorio L. Katis, Elizabeth L. Zoeller, Min Qui, Allan I. Levey, O. Gileadi, Haian Fu

This paper develops a time-resolved fluorescence resonance energy transfer (TR-FRET) assay for screening small molecule inhibitors targeting the SYK and FCER1G interaction, identifying hematoxylin as a hit.

SLAS DISCOVERY · Aug 23, 2024Peer-reviewedPharmacology & Toxicology

Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM

Frances M. Bashore, Vittorio L. Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J. Bradshaw, Karolina A. Rygiel, Tina M. Leisner, Rod Chalk, Swati Mishra, Andrew C. Williams, O. Gileadi, Paul E. Brennan, Jesse C. Wiley, Jake Gockley, , Alison Donnelly Axtman

The paper identifies two covalent inhibitors that disrupt the interaction between SYK's tandem SH2 domains and FCER1G phospho-ITAM, potentially beneficial for Alzheimer's disease therapy.

PLoS ONE · Feb 15, 2024Peer-reviewedNeuroscience

Development of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic strategy for Alzheimer's disease.

Yuhong Du, William J. Bradshaw, Tina M. Leisner, Joel K. Annor‐Gyamfi, Kun Qian, Frances M. Bashore, Arunima Sikdar, Felix O. Nwogbo, Andrei A. Ivanov, Stephen V. Frye, O. Gileadi, Paul E. Brennan, Allan I. Levey, Alison Donnelly Axtman, Kenneth H. Pearce, , Vittorio L. Katis

This study identifies MSN and CD44 as potential therapeutic targets for Alzheimer's disease by developing inhibitors of their interaction through structural and chemical screening.

Journal of Biological Chemistry · Oct 21, 2023Peer-reviewedMolecular Biology