Amyloidogenic regions in beta-strands II and III modulate the aggregation and toxicity of SOD1 in living cells
Luke McAlary, Jeremy R. Nan, Clay Shyu, Mine Sher, Steven Samuel Plotkin, Neil R. Cashman
The paper identifies amyloidogenic regions in beta-strands II and III of SOD1 that modulate aggregation and toxicity in ALS mutants, showing that proline mutations reduce these effects.
Open Biology · Jun 1, 2024Peer-reviewedMolecular Biology