Steven Samuel Plotkin

The paper examines how the binding selectivity of amyloid-beta antibodies to toxic oligomers correlates with therapeutic efficacy and reduced risk of adverse effects in Alzheimer's disease.

This study establishes a self-sustaining lab culture system for Mnemiopsis leidyi, achieving reproductive success comparable to wild-caught individuals using a co-cultured diet of rotifers and copepods.

The paper identifies amyloidogenic regions in beta-strands II and III of SOD1 that modulate aggregation and toxicity in ALS mutants, showing that proline mutations reduce these effects.

The paper identifies TRAF6 as an interactor of misfolded SOD1 in ALS, showing it promotes aggregation through ubiquitination.

The paper designs and tests SOD1 mutants using computational methods, showing that a destabilizing mutant causes ALS-like phenotypes while a stabilizing mutant rescues them in zebrafish.