ThermoLink: Bridging Disulfide Bond and EnzymeThermostability through Database Construction andMachine Learning Prediction
Ran Xu, Qican Pan, Guoliang Zhu, Yilin Ye, Minghui Xin, Zechen Wang, Sheng Wang, Weifeng Li, Yanjie Wei, Jingjing Guo, Liangzhen Zheng
The paper curates a database of disulfide bonds and their effects on protein thermostability, develops machine learning models to predict beneficial disulfide bonds, and demonstrates the utility of AlphaFold2 for this task.
Protein Science · Aug 15, 2024Peer-reviewedBioinformatics