BioinformaticsProtein SciencePeer-reviewed
ThermoLink: Bridging Disulfide Bond and EnzymeThermostability through Database Construction andMachine Learning Prediction
Ran Xu, Qican Pan, Guoliang Zhu…·Liangzhen Zheng
The paper curates a database of disulfide bonds and their effects on protein thermostability, develops machine learning models to predict beneficial disulfide bonds, and demonstrates the utility of AlphaFold2 for this task.