Author

Guoliang Zhu

East China University of Science and TechnologyORCID 0000-0002-2804-8175Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Approach:deep learning· 2 Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1 Research Focus:database / resource· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Liangzhen ZhengiD· 2 shared Lixin ZhangiD· 2 shared Sheng WangiD· 2 shared Weifeng LiiD· 2 shared Xueting LiuiD· 2 shared Zechen WangiD· 2 shared Bin Zhu· 1 shared Cuicui Men· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioinformatics

Liangzhen ZhengORCID

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Author profile →

4 papers

Recent·Most cited

TRACER navigates rearrangement-driven sesterterpene chemical space via multimodal enzyme-product representation learning

Cuiping Xing, Kangjie Lv, Weiyan Zhang, Yuwei Chen, Keying Lan, Guoliang Zhu, Bin Zhu, Shou‐Mao Shen, Xinjun Zhang, Yucheng Gu, Yue‐Wei Guo, Hideaki Oikawa, Tom Hsiang, Lixin Zhang, Youyuan Li, , Xueting Liu

TRACER predicts terpene skeletal rearrangements by learning enzyme-product associations, identifying novel carbon skeletons and mechanistic insights.

bioRxiv · Aug 19, 2026 · PreprintSynthetic Biology

Benchmarking AlphaFold3-like Methods for Protein-Peptide Complex Prediction

Fan Zhou, Shangwei Guo, Xiangda Peng, Shuhan Zhang, Cuicui Men, Xiaobo Duan, Guoliang Zhu, Zechen Wang, Weifeng Li, Yuguang Mu, Liangzhen Zheng, Haibin Liu, Sheng Wang

This study benchmarks AlphaFold3-like methods for predicting protein-peptide complex structures, showing improved accuracy but challenges in binding site prediction.

bioRxiv · Mar 9, 2025 · PreprintBioinformatics

ThermoLink: Bridging Disulfide Bond and EnzymeThermostability through Database Construction andMachine Learning Prediction

Ran Xu, Qican Pan, Guoliang Zhu, Yilin Ye, Minghui Xin, Zechen Wang, Sheng Wang, Weifeng Li, Yanjie Wei, Jingjing Guo, Liangzhen Zheng

The paper curates a database of disulfide bonds and their effects on protein thermostability, develops machine learning models to predict beneficial disulfide bonds, and demonstrates the utility of AlphaFold2 for this task.

Protein Science · Aug 15, 2024Peer-reviewedBioinformatics

Simple cloning of large natural product biosynthetic gene clusters from Streptomyces by an engineered CRISPR/Cas12a system

Mindong Liang, Leshi Liu, Fei Xu, Xiaoqian Zeng, Ruijun Wang, Yang Jinling, Weishan Wang, Loganathan Karthik, Jiakun Liu, Zhiheng Yang, Guoliang Zhu, Shuliu Wang, Linquan Bai, Yaojun Tong, Xueting Liu, , Gao‐Yi Tan

The paper develops a method to efficiently clone large GC-rich BGCs from Streptomyces genomes using a CRISPR/Cas12a-based system, demonstrating its effectiveness with a 87-kb BGC.

Nucleic Acids Research · Mar 10, 2022Peer-reviewedSynthetic Biology