Spatial 5mC-seq profiling of embryos and decidua after implantation in mammal
Xun Shan, Yimin Tang, Jinzhou Hu, Mingyuan Bian, Xuelong Yao, Lei Gao, JL Liu
The paper develops a spatial DNA methylation profiling method called SmC-seq and applies it to study DNA methylation dynamics in mouse embryos and decidua after implantation, revealing spatial heterogeneity and functional roles of hypomethylated regions in nutrient provision.
Nature Methods · Apr 27, 2026Peer-reviewedGenomics