Jiang Liu

This study identifies C1R as a molecular link between coronary artery disease and dementia through proteogenomic analysis of circulating proteins and genetic causal-inference.

The paper develops a spatial DNA methylation profiling method called SmC-seq and applies it to study DNA methylation dynamics in mouse embryos and decidua after implantation, revealing spatial heterogeneity and functional roles of hypomethylated regions in nutrient provision.

The paper identifies fetal cis-regulatory elements in the human genome using single-cell multi-omics analysis, revealing thousands of organ- and cell-type-specific regulatory elements.

This study investigates DNA methylation reprogramming during zebrafish sex determination and transition, showing its role in germline development and sexual plasticity.

This study identifies ZCWPW1 as an H3K4me3 reader required for DSB repair and synapsis in mouse testes, showing its dependency on PRDM9 activity.