Author

Lei Gao

Chinese Academy of SciencesORCID 0000-0002-0882-7518Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Jiang LiuiD· 3 shared Chao LiuiD· 1 shared Chuanxin ZhangiD· 1 shared Dahua CheniD· 1 shared Gang LüiD· 1 shared Gaobo WeiiD· 1 shared Hongbin LiuiD· 1 shared Jian ZhangiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersDevelopmental Biology

Jiang LiuORCID

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3 papers

Recent·Most cited

Spatial 5mC-seq profiling of embryos and decidua after implantation in mammal

Xun Shan, Yimin Tang, Jinzhou Hu, Mingyuan Bian, Xuelong Yao, Lei Gao, JL Liu

The paper develops a spatial DNA methylation profiling method called SmC-seq and applies it to study DNA methylation dynamics in mouse embryos and decidua after implantation, revealing spatial heterogeneity and functional roles of hypomethylated regions in nutrient provision.

Nature Methods · Apr 27, 2026Peer-reviewedGenomics

DNA Methylation Reprogramming during Sex Determination and Transition in Zebrafish

Xinxin Wang, Xin Ma, Gaobo Wei, Weirui Ma, Zhen Zhang, Xuepeng Chen, Lei Gao, Zhenbo Liu, Yue Yuan, Lizhi Yi, Jun Wang, Toshinobu Tokumoto, Junjiu Huang, Dahua Chen, Jian Zhang, Jiang Liu

This study investigates DNA methylation reprogramming during zebrafish sex determination and transition, showing its role in germline development and sexual plasticity.

Genomics Proteomics & Bioinformatics · Feb 1, 2021Peer-reviewedDevelopmental Biology

The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double strand break repair

Tao Huang, Shenli Yuan, Lei Gao, Mengjing Li, Xiaochen Yu, Jianhong Zhan, Yingying Yin, Chao Liu, Chuanxin Zhang, Gang Lü, Wei Li, Jiang Liu, Zi‐Jiang Chen, Hongbin Liu

This study identifies ZCWPW1 as an H3K4me3 reader required for DSB repair and synapsis in mouse testes, showing its dependency on PRDM9 activity.

eLife · May 6, 2020Peer-reviewedDevelopmental Biology