Mitochondria dysfunction in Charcot Marie Tooth 2B Peripheral Sensory Neuropathy
Yingli Gu, Flora Guerra, Mingzheng Hu, Alexander Pope, Kijung Sung, Wanlin Yang, Simone Jetha, Thomas A. Shoff, Tessanya Gunatilake, Owen Dahlkamp, Linda Zhixia Shi, Fiore Manganelli, Maria Nolano, Yue Zhou, Jianqing Ding, , Chengbiao Wu
This study investigates how the Rab7V162M mutation in CMT2B affects mitochondrial morphology and function in fibroblasts and neurons, showing mitochondrial fragmentation and dysregulated movement.
Communications Biology · Jul 18, 2022Peer-reviewedNeuroscience