Author

Yingli Gu

Harbin Medical UniversityORCID 0000-0002-5249-3535Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Assay:proteomics· 1

Frequent Co-Authors

Chengbiao WuiD· 4 shared William Cary MobleyiD· 3 shared Alexander Pope· 2 shared Charlene Smith-GeateriD· 2 shared Judith FrydmaniD· 2 shared Kijung SungiD· 2 shared Leslie Michels ThompsoniD· 2 shared Linda Zhixia ShiiD· 2 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersNeuroscience

Chengbiao WuORCID

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4 papers

Recent·Most cited

BDNF and TRiC-inspired Reagents Rescue Cortical Synaptic Deficits in a Mouse Model of Huntington's Disease

Yingli Gu, Alexander Pope, Charlene Smith-Geater, Christopher Carmona, Aaron D. Johnstone, Linda Zhixia Shi, Xu‐Qiao Chen, Sarai A. Santos, Claire Cecile Bacon-Brenes, Thomas A. Shoff, Korbin M. Kleczko, Judith Frydman, Leslie Michels Thompson, William Cary Mobley, Chengbiao Wu

This study shows that BDNF and TRiC-inspired reagents can rescue synaptic deficits in HD mouse models.

Neurobiology of Disease · Apr 10, 2024Peer-reviewedNeuroscience

CryoET Reveals Organelle Phenotypes in Huntington Disease Patient iPSC-Derived and Mouse Primary Neurons

Gong‐Her Wu, Charlene Smith-Geater, Jesús G. Galaz-Montoya, Yingli Gu, Sanket Rajan Gupte, Ranen Aviner, Patrick Mitchell, Joy Hsu, Ricardo Miramontes, Keona Q. Wang, Nicolette R. Geller, Cathy Hou, Cristina Danita, Lydia‐Marie Joubert, Michael F. Schmid, , Wah Chiu

This study uses cryoET and proteomics to identify mitochondrial and organelle abnormalities in HD models, showing potential for early diagnosis and therapy development.

Nature Communications · Feb 8, 2023Peer-reviewedNeuroscience

Mitochondria dysfunction in Charcot Marie Tooth 2B Peripheral Sensory Neuropathy

Yingli Gu, Flora Guerra, Mingzheng Hu, Alexander Pope, Kijung Sung, Wanlin Yang, Simone Jetha, Thomas A. Shoff, Tessanya Gunatilake, Owen Dahlkamp, Linda Zhixia Shi, Fiore Manganelli, Maria Nolano, Yue Zhou, Jianqing Ding, , Chengbiao Wu

This study investigates how the Rab7V162M mutation in CMT2B affects mitochondrial morphology and function in fibroblasts and neurons, showing mitochondrial fragmentation and dysregulated movement.

Communications Biology · Jul 18, 2022Peer-reviewedNeuroscience

Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception

Kijung Sung, Luiz F. Ferrari, Wanlin Yang, ChiHye Chung, Xiaobei Zhao, Yingli Gu, Suzhen Lin, Kai Zhang, Bianxiao Cui, Matthew L. Pearn, Michael T. Maloney, William Cary Mobley, Jon D. Levine, Chengbiao Wu

This study investigates the NGFR100W mutation in NGF, showing it supports neuronal survival via TrkA but fails to activate p75NTR, distinguishing trophic from nociceptive signaling.

Journal of Neuroscience · Feb 26, 2018Peer-reviewedNeuroscience