Author

Alexander Pope

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:protein structure· 1

Frequent Co-Authors

Chengbiao WuiD· 2 shared Linda Zhixia ShiiD· 2 shared Thomas A. ShoffiD· 2 shared Yingli GuiD· 2 shared Aaron D. Johnstone· 1 shared Binh An NguyeniD· 1 shared Cecilia BucciiD· 1 shared Charlene Smith-GeateriD· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersNeuroscience

Chengbiao WuORCID

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Author profile →

3 papers

Recent·Most cited

BDNF and TRiC-inspired Reagents Rescue Cortical Synaptic Deficits in a Mouse Model of Huntington's Disease

Yingli Gu, Alexander Pope, Charlene Smith-Geater, Christopher Carmona, Aaron D. Johnstone, Linda Zhixia Shi, Xu‐Qiao Chen, Sarai A. Santos, Claire Cecile Bacon-Brenes, Thomas A. Shoff, Korbin M. Kleczko, Judith Frydman, Leslie Michels Thompson, William Cary Mobley, Chengbiao Wu

This study shows that BDNF and TRiC-inspired reagents can rescue synaptic deficits in HD mouse models.

Neurobiology of Disease · Apr 10, 2024Peer-reviewedNeuroscience

Mitochondria dysfunction in Charcot Marie Tooth 2B Peripheral Sensory Neuropathy

Yingli Gu, Flora Guerra, Mingzheng Hu, Alexander Pope, Kijung Sung, Wanlin Yang, Simone Jetha, Thomas A. Shoff, Tessanya Gunatilake, Owen Dahlkamp, Linda Zhixia Shi, Fiore Manganelli, Maria Nolano, Yue Zhou, Jianqing Ding, , Chengbiao Wu

This study investigates how the Rab7V162M mutation in CMT2B affects mitochondrial morphology and function in fibroblasts and neurons, showing mitochondrial fragmentation and dysregulated movement.

Communications Biology · Jul 18, 2022Peer-reviewedNeuroscience

Structural polymorphism of amyloid fibrils in cardiac ATTR amyloidosis revealed by cryo-electron microscopy

Binh An Nguyen, Shumaila Afrin, Virender Pratap Singh, Yasmin Ahmed, Rose Pedretti, María del Carmen Fernández‐Ramírez, Merrill Douglas Benson, Michael R. Sawaya, Preeti Singh, Qin Cao, David R. Boyer, Alexander Pope, Paweł M. Wydorski, Siddharth Kumar, Farzeen Chhapra, , Lorena Saelices

The paper uses cryo-electron microscopy to show that cardiac ATTR amyloid fibrils are structurally polymorphic, independent of genotype and phenotype, challenging the one-fibril-fold-per-disease paradigm.

bioRxiv · Jun 21, 2022 · PreprintMolecular Biology