Longitudinal sequencing reveals polygenic andepistatic nature of genomic response to selection
Simon K. G. Forsberg, Diogo Melo, Scott Wolf, Jennifer K. Grenier, Minjia Tang, Lucas P. Henry, Luisa F. Pallares, Andrew G. Clark, Julien F. Ayroles
This study uses longitudinal sequencing in Drosophila to show that genomic response to selection involves both polygenic shifts and epistatic interactions, with DEGs enriched for selected SNPs.
Proceedings of the National Academy of Sciences · Jun 18, 2025Peer-reviewedEvolutionary Biology