Influence of Macrocyclization Strategies on DNA-Encoded Cyclic Peptide Libraries
Hanqing Zhao, Xue Li, Xueyu Yao, Shijie Zhang, Yandan Bao, Weiwei Lu, Minyan Xing, Xudong Wang, Xuan Wang, Yujun Zhao, Qian Chu, Xiaojie Lu
This study evaluates how different macrocyclization strategies affect DNA-encoded cyclic peptide library selections against MDM2 and GIT1, identifying potent inhibitors and elucidating binding mechanisms.
JACS Au · Jun 27, 2025Peer-reviewedBiochemistry