HER2 mutation-derived neoantigens in NSCLC as actionable targets for TCR therapy
Amanda Montoya, Hui Nie, Peixin Jiang, Jared K. Slone, Yulia V. Shulga, Anika Patel, Prashant S. Menon, Isabella Polic, Emily Bontekoe, Lingzhi Hong, Minying Zhang, Emane Rose Assita, Sarah Forward, Changsheng Xing, Bo Jiang, , Alexandre Reuben
The paper identifies TCRs targeting HER2 mutations in NSCLC, showing they recognize mutant epitopes and maintain cytotoxic activity, offering a potential immunotherapy strategy.
bioRxiv · Aug 4, 2026 · PreprintImmunology