ImmunologybioRxivPreprint
Antibodies with Engineered Fc Domains Having Absolute Binding Selectivity to either FcγRIIa or FcγRI Delineate the Respective Effector Phenotypes by Human Monocytes and Macrophages
Katia George, Sanghwan Ko, Seema Irani…·George Georgiou
This study uses Fc-engineered antibodies to selectively engage FcγRIIa or FcγRI, revealing their distinct effector functions in human monocytes and macrophages.
DOI 10.64898/2026.08.31.748147