Preclinical Characterization of Hippo pathway inhibition: Insights from Pharmacological and Genetic Studies
Sayantanee Paul, Michelle L. Lepherd, Thijs J. Hagenbeek, Satoko Kakiuchi-Kiyota, Mioaran Ning, Minyi Shi, Bence Dániel, Ryan Ybarra, Jessica Sims, Anwesha Dey
This paper investigates the effects of Hippo pathway inhibition through pharmacological and genetic approaches, identifying kidney, pancreas, and thymus as target organs with dose-dependent toxicities.
bioRxiv · Aug 4, 2026 · PreprintCancer Biology