Thijs J. Hagenbeek

This paper investigates the effects of Hippo pathway inhibition through pharmacological and genetic approaches, identifying kidney, pancreas, and thymus as target organs with dose-dependent toxicities.

The paper identifies small molecules that induce a cofactor switch in TEAD proteins from YAP to VGLL4, repressing pro-growth gene networks and showing anti-proliferative effects.

This study shows that mesothelioma cells develop drug resistance by reverting to a promoter-centric gene regulation mechanism when treated with a TEAD inhibitor.