Mechanism of single-strand annealing from native mass spectrometry and cryo-EM structures of RAD52 homolog Mgm101
Carter T. Wheat, Zihao Qi, Miqdad Hussain, Katerina Zakharova, Vicki Hopper Wysocki, Charles E. Bell
This study determines the structure of Mgm101, a RAD52 homolog, and reveals its single-strand annealing mechanism using cryo-EM and mass spectrometry, showing it anneals ssDNAs on the same ring in cis.
Nucleic Acids Research · Mar 27, 2026Peer-reviewedBiochemistry