Miram Meziane

Reconstructing signaling histories of single cells via perturbation screens and transfer learning

The paper develops a framework combining perturbation screens and transfer learning to reconstruct signaling histories in cells and optimize differentiation protocols.

Integrative vasculogenesis unifies distinct endothelial sources in the developing lung

The paper identifies a mesenchymal progenitor population in the developing mouse lung that generates endothelial cells through integrative vasculogenesis, distinct from classical vasculogenesis and angiogenesis.

Diffusion barriers imposed by tissue topology shape morphogen gradients

The paper shows SCUBE1 expands Hedgehog gradients by enabling transient diffusion through cell gaps, revealing a topology-limited diffusion mechanism for morphogen signaling.