Prashant Chandrasekaran

A Single-Cell Atlas of PVOD Across the Lifespan Reveals Cellular and Molecular Therapeutic Targets

The paper constructs a single-cell atlas of PVOD across the lifespan, identifying endothelial dysfunction and molecular pathways as key drivers of the disease with potential therapeutic targets.

Integrative vasculogenesis unifies distinct endothelial sources in the developing lung

The paper identifies a mesenchymal progenitor population in the developing mouse lung that generates endothelial cells through integrative vasculogenesis, distinct from classical vasculogenesis and angiogenesis.

A postnatal human lung developmental atlas reveals windows of genetic vulnerability to chronic lung disease

The paper creates a postnatal human lung developmental atlas to identify genes linked to chronic lung disease risk and shows COPD genetic risk is enriched in genes active during early postnatal endothelial development.

Endodermal BRD4 mediates epithelial-mesenchymal crosstalk during lung development

This study shows that BRD4 in endodermal cells is crucial for lung development by facilitating epithelial-mesenchymal crosstalk, proper lineage allocation, and branching morphogenesis.

A CXCL12 morphogen gradient uncovers lung endothelial heterogeneity and promotes distal vascular growth

The paper identifies a CXCL12 morphogen gradient in developing pulmonary vasculature, revealing endothelial heterogeneity and its role in vascular growth.