The paper tracks chromatin dynamics across seven orders of magnitude in human and mouse cells, finding strongly subdiffusive behavior with limited sensitivity to transcription and histone modifications.

Nature Structural & Molecular Biology · May 4, 2026Peer-reviewedBiophysics

Binding domain mutations provide insight into CTCF's relationship with chromatin and its contribution to gene regulation

Catherine Do, Guimei Jiang, Giulia Cova, Christos C. Katsifis, Domenic N. Narducci, Theodore Sakellaropoulos, Raphael Silveira Vidal, Priscillia Lhoumaud, Aristotelis Tsirigos, Fara Faye Regis, Nata Kakabadze, Elphège Pierre Nora, Marcus B. Noyes, Anders S. Hansen, Jane A. Skok

The paper investigates how CTCF mutations affect chromatin accessibility, cohesin binding, and gene regulation through multivariate modeling and mutant perturbations.

Cell Genomics · Mar 20, 2025Peer-reviewedMolecular Biology

Putative Looping Factor ZNF143/ZFP143 is an Essential Transcriptional Regulator with No Looping Function

Domenic N. Narducci, Anders S. Hansen

The paper shows ZNF143/ZFP143 is an essential transcription factor with no general looping function, functioning independently of CTCF and regulating mitochondrial and ribosomal genes.

Molecular Cell · Dec 20, 2024Peer-reviewedGenetics

Diffusion barriers imposed by tissue topology shape morphogen gradients

Gavin Schlissel, Miram Meziane, Domenic N. Narducci, Anders S. Hansen, Pulin Li

The paper shows SCUBE1 expands Hedgehog gradients by enabling transient diffusion through cell gaps, revealing a topology-limited diffusion mechanism for morphogen signaling.

Proceedings of the National Academy of Sciences · Aug 27, 2024Peer-reviewedDevelopmental Biology