The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition
Gülnihal Kavaklıoğlu, Alexandra Podhornik, Terezia Vcelkova, Jelena Marjanović, Mirjam A Beck, Trinh Phan-Canh, Theresia Mair, Claudia Miccolo, Aleksej Drino, Mirko Doni, Gerda Egger, Susanna Chiocca, Miha Modic, Christian Seiser
This study identifies L1TD1's role in promoting LINE-1 retrotransposition by interacting with L1 ORF1p, linking it to cancer progression and early development.
eLife · Mar 20, 2025Peer-reviewedGenetics