Author

Christian Seiser

Medical University of ViennaORCID 0000-0002-7046-9352Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:differential expression· 3 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Gerda EggeriD· 2 shared Terezia VcelkovaiD· 2 shared Adrian Peter BirdiD· 1 shared Aleksej DrinoiD· 1 shared Alexandra PodhornikiD· 1 shared Ana‐Iris SchieferiD· 1 shared Anna MalzeriD· 1 shared Bernard H. Ramsahoye· 1 shared

Activity by Year

2017-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

Gerda EggerORCID

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4 papers

Recent·Most cited

HDAC1 acts as tumor suppressor in ALK-positive anaplastic large-cell lymphoma: Implications for HDAC inhibitor therapy

Maša Zrimšek, Kristina Draganić, Anna Malzer, Verena Doblmayr, Katarina Mišura, Rafael de Freitas e Silva, Jamie D. Matthews, Fabio Iannelli, Sabrina Wohlhaupter, Carlos Uziel Pérez Malla, Heinz Fischer, Helga Schachner, Ana‐Iris Schiefer, Raheleh Sheibani‐Tezerji, Roberto Chiarle, , Gerda Egger

This study shows HDAC1 suppresses ALK-positive lymphoma growth, but systemic HDAC inhibition can still be therapeutic.

Leukemia · Apr 2, 2025Peer-reviewedCancer Biology

The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition

Gülnihal Kavaklıoğlu, Alexandra Podhornik, Terezia Vcelkova, Jelena Marjanović, Mirjam A Beck, Trinh Phan-Canh, Theresia Mair, Claudia Miccolo, Aleksej Drino, Mirko Doni, Gerda Egger, Susanna Chiocca, Miha Modic, Christian Seiser

This study identifies L1TD1's role in promoting LINE-1 retrotransposition by interacting with L1 ORF1p, linking it to cancer progression and early development.

eLife · Mar 20, 2025Peer-reviewedGenetics

GSE1 links the HDAC1/CoREST co-repressor complex to DNA damage

Terezia Vcelkova, Wolfgang Reiter, Martha Zylka, David Maria Hollenstein, Stefan Schuckert, Markus Hartl, Christian Seiser

This study identifies GSE1 as a component of the HDAC1/CoREST complex involved in DNA damage response, revealing its role in DDR signaling and histone modification regulation.

Nucleic Acids Research · Oct 6, 2023Peer-reviewedMolecular Biology

Domains of methylated CAC and CG target MeCP2 to tune transcription in the brain

Sabine Lagger, John C. Connelly, Gabriele Schweikert, Shaun Webb, Jim Selfridge, Bernard H. Ramsahoye, Miao Yu, Dina DeSousa, Christian Seiser, Chuan He, Guido Sanguinetti, Lawrence C. Sowers, Malcolm D. Walkinshaw, Adrian Peter Bird

The paper shows MeCP2 binds to mCG and mCAC sequences in mouse brain, with binding density correlating with transcriptional regulation of neuronal genes.

PLoS Genetics · May 12, 2017Peer-reviewedMolecular Biology