Miha Modic

HCR-Proxy resolves site-specific proximal RNA proteomes at subcompartmental nanoscale resolution

HCR-Proxy maps RNA-proximal proteomes at subcompartmental resolution, revealing sequence-encoded protein partitioning in nucleolar condensates.

Integrative profiling of condensation-prone RNAs during early development

The paper identifies a class of condensation-prone RNAs during early development and reveals their sequence and structural features using deep learning.

The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition

This study identifies L1TD1's role in promoting LINE-1 retrotransposition by interacting with L1 ORF1p, linking it to cancer progression and early development.

Flow: a web platform and open database to analyse, store, curate and share bioinformatics data at scale

Flow provides a web platform and database for managing and analyzing large-scale bioinformatics data, addressing challenges in data processing, quality, and accessibility.

Epiblast morphogenesis is controlled by selective mRNA decay triggered by LIN28A relocation

The paper identifies LIN28A as a key factor in mRNA decay during epiblast morphogenesis, linking cell identity changes to embryonic growth through nucleo-cytoplasmic translocation.

Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive demethylation in mammals

The paper identifies DPPA3 as a driver of genome-wide passive DNA demethylation in mammals, showing it can bypass TET protein requirements and function across species.

Widespread FUS mislocalization is a molecular hallmark of ALS

The paper investigates FUS mislocalization in ALS, finding it occurs in both VCP-mutation related and sporadic ALS, and links it to aberrant intron retention in SFPQ transcripts.