Acat1 gene KO restores TGN cholesterol deficiency in mutant NPC1 cells and expands mutant Npc1 mouse lifespan
Maximillian A. Rogers, Catherine C.Y. Chang, Robert A. Maue, Elaina Marie Melton, Andrew A. Peden, William Sherman Garver, Mitchell M. Huang, Peter W. Schroen, Ta‐Yuan Chang
The paper shows that Acat1 gene knockout improves cholesterol levels and extends lifespan in mutant Npc1 mice by correcting cholesterol mislocalization.
bioRxiv · Aug 7, 2020 · PreprintNeuroscience