Ta‐Yuan Chang

Inhibiting the cholesterol storage enzyme ACAT1/SOAT1 in aging Apolipoprotein E4 mice alter their brains inflammatory profiles

This study shows that inhibiting ACAT1/SOAT1 in APOE4 mice reduces brain inflammation by lowering cholesterol esters and TLR4 levels.

Stealth liposomes encapsulating a potent ACAT1/SOAT1 inhibitor F12511: pharmacokinetic, biodistribution and toxicity studies in wild-type mice, and efficacy studies in triple transgenic Alzheimer Disease mice.

This study evaluates a nanoparticle-formulated ACAT1 inhibitor in mice, showing brain delivery and reduced AD pathology without toxicity.

ACAT1/SOAT1 Blockade Suppresses LPS-Mediated Neuroinflammation by Modulating the Fate of Toll-Like Receptor 4 in Microglia

This study shows that blocking ACAT1 in microglia reduces LPS-induced neuroinflammation by altering TLR4 trafficking and degradation.

Acat1 gene KO restores TGN cholesterol deficiency in mutant NPC1 cells and expands mutant Npc1 mouse lifespan

The paper shows that Acat1 gene knockout improves cholesterol levels and extends lifespan in mutant Npc1 mice by correcting cholesterol mislocalization.