Self-reinforcing ROS-aneuploidy feedback loop shapes preimplantation development
Seok Hee Lee, Andrew Alamban, Rhodel K. Simbulan, Philip J. Marsh, Mitchell P. Rosen, Mustafa G. Aydogan, Paolo F. Rinaudo
The paper identifies a self-reinforcing ROS-aneuploidy feedback loop in preimplantation development, showing that oxidative stress can induce persistent chromosomal alterations.
bioRxiv · Jul 22, 2026 · PreprintDevelopmental Biology