Developmental BiologybioRxivPreprint
Self-reinforcing ROS-aneuploidy feedback loop shapes preimplantation development
Seok Hee Lee, Andrew Alamban, Rhodel K. Simbulan…·Paolo F. Rinaudo
The paper identifies a self-reinforcing ROS-aneuploidy feedback loop in preimplantation development, showing that oxidative stress can induce persistent chromosomal alterations.