Inhibiting proBDNF to mature BDNF conversion leads to autism-like phenotypes in vivo
He You, Toshiyuki Mizui, Kazuyuki Kiyosue, Keizo Takao, Tsuyoshi Miyakawa, Koichi Kato, Mitsuru Otsuka, Ting Bai, Kun Xia, Bai Lu, Masami Kojima
This study shows that inhibiting proBDNF to mBDNF conversion in mice leads to autism-like behaviors, suggesting proBDNF as a potential blood marker and therapeutic target for ASD.
bioRxiv · Jun 12, 2020 · PreprintNeuroscience