Tsuyoshi Miyakawa

RFind-sc maps single cells onto biological axes defined by external gene signatures, revealing cell states and candidate genes for stress responses.

The paper shows that repetitive neuronal activation induces nuclear reprogramming, leading to cellular maturation state changes with behavioral effects similar to ECT.

The paper demonstrates that baseline-normalized metrics are essential for accurately interpreting fear memory in mice, showing that conventional freezing scores confound locomotor activity.

This study decodes multiple navigational information types from DG neuron activity in mice, showing independent encoding of position, speed, motion direction, and future location.

This study shows that lysine lactylation in brain cells is induced by neural excitation and behavioral stimuli, affecting mood-related behaviors.

This study shows that inhibiting proBDNF to mBDNF conversion in mice leads to autism-like behaviors, suggesting proBDNF as a potential blood marker and therapeutic target for ASD.

This study shows that Polβ suppresses DNA double-strand breaks during active DNA demethylation in postnatal hippocampal development, which is essential for proper neuronal differentiation and behavior.

This study examines the effects of fluoxetine on hippocampal neurons and cortical neurogenesis in marmosets, finding increased immature neuron markers and changes in interneurons.

The paper identifies a shared transcriptomic pseudoimmaturity induced by neural hyperexcitation across multiple neuropsychiatric disorders.

The paper confirms lower brain pH in schizophrenia and bipolar disorder patients and shows it persists in animal models, suggesting it is a pathophysiological feature rather than an artifact.