Golgi retention of KIT in gastrointestinal stromal tumour cells is phospholipase D activity-dependent
Yuuki Obata, Miyuki Natsume, Isamu Shiina, Tsuyoshi Takahashi, Toshirou Nishida
This study shows that KIT mutant retention in the Golgi/TGN in GISTs depends on the PLCγ2-PKD2-PLD2 pathway, leading to signal inactivation upon PLD inhibition.
Scientific Reports · Aug 6, 2025Peer-reviewedCell Biology