A novel sorting method reveals superior metabolic activity of mononucleated over binucleated tetraploid hepatocytes
Yusuke Watanabe, Jonathan Sussman, Tomoya Anami, Moena Hattori, Saaya Yamane, Masaki Nishikawa, Yasuyuki Sakai, Takeshi Katsuda
This study develops a flow cytometry method to distinguish mononucleated and binucleated tetraploid hepatocytes, revealing that mononucleated cells have more metabolically active gene expression.
bioRxiv · May 7, 2025 · PreprintCell Biology