Spatiotemporal Single-Cell Analysis Reveals T Cell Clonal Dynamics and Phenotypic Plasticity in Human Graft-versus-Host Disease
Lingting Shi, Ajna Uzuni, Ximi Kevin Wang, Michael Pressler, David W Harle, Shami Chakrabarti, Rodney Macedo, Kirubel Belay, Christian A. Gordillo, Erik Raps, Jia Yi Zhang, Achille Nazaret, Joy Linyue Fan, Yinuo Jin, Xin Shen, , Ran Reshef
This study uses spatiotemporal single-cell analysis to track T cell clonal dynamics and phenotypic plasticity in GVHD, revealing links between TCR features, clonal expansion, and disease severity.
bioRxiv · May 24, 2025 · PreprintSystems Biology