Ran Reshef

The paper identifies a T-cell receptor structural signature that predicts acute GVHD risk by analyzing alloreactive clonotypes and introduces a metric to quantify clonal dominance.

The paper identifies co-expression patterns of chemokine receptors on CD8+ T cells that distinguish anti-tumor efficacy from off-target toxicity in melanoma.

This study uses spatiotemporal single-cell analysis to track T cell clonal dynamics and phenotypic plasticity in GVHD, revealing links between TCR features, clonal expansion, and disease severity.

This study shows CXCL12 gradients around TMEM doorways promote tumor cell invasion and create immunosuppressive niches by affecting CD8+ T cell function and distribution.