David W Harle

A Donor T-Cell Receptor Structural Signature Determines Alloreactive Potential and Predicts Acute Graft-Versus-Host Disease

The paper identifies a T-cell receptor structural signature that predicts acute GVHD risk by analyzing alloreactive clonotypes and introduces a metric to quantify clonal dominance.

A Conserved Landscape of Chemokine Receptor Co-expression Defines the Functional States of CD8+ T Cells in Melanoma

The paper identifies co-expression patterns of chemokine receptors on CD8+ T cells that distinguish anti-tumor efficacy from off-target toxicity in melanoma.

Spatiotemporal Single-Cell Analysis Reveals T Cell Clonal Dynamics and Phenotypic Plasticity in Human Graft-versus-Host Disease

This study uses spatiotemporal single-cell analysis to track T cell clonal dynamics and phenotypic plasticity in GVHD, revealing links between TCR features, clonal expansion, and disease severity.

A CXCR4 partial agonist improves immunotherapy by targeting polymorphonuclear myeloid-derived suppressor cells and cancer-driven granulopoiesis

This paper shows that a CXCR4 partial agonist enhances immunotherapy in gastric cancer by targeting PMN-MDSCs and granulopoiesis.