Methionine dependence in cancer cells due tolack of B12-dependent methionine synthase activity
Mohamed El Husseiny, Roland Nilsson
This study identifies B12 deficiency as the cause of methionine dependence in cancer cells, showing that restoring B12 rescues growth on homocysteine and reduces metastatic potential.
bioRxiv · Feb 27, 2025 · PreprintCancer Biology