Generation and Validation of a Lower Limb Muscle Single-Cell RNA Sequencing Data Set Identifies Pathogenic Endothelial Metabolism in Peripheral Arterial Disease
Mohamed Nofal, Suhib Alhusban, Qimei Han, Adeleigh Pressley, Samantha O’Keefe, Silvia Leanhart, Kevin W. Southerland, Joseph M. McClung, Brian Herb Annex
The paper generates and validates a single-cell RNA-seq dataset to identify pathogenic endothelial metabolism in peripheral arterial disease, showing cell-type specific metabolic changes in CLTI.
bioRxiv · Sep 23, 2025 · PreprintBioinformatics